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prostate health index
Indications:
- option for prostate cancer screening (FDA-approved in 2012)
Procedure:
- calculated from measurements of total serum PSA, free PSA, & an isoform of PSA called [-2]proPSA
Clinical significance:
- sensitivity 90%, specificity 30% at cutoff score of 28.6
- false positive rates high
- uncertain whether benefits of screening outweigh potential harms [1]
General
risk assessment
References
- Brett AS
Prostate Health Index: A Relatively New Screening Test for
Prostate Cancer
NEJM Journal Watch. April 7, 2015
Massachusetts Medical Society
(subscription needed) http://www.jwatch.org
- Loeb S et al.
The Prostate Health Index selectively identifies clinically
significant prostate cancer.
J Urol 2015 Apr; 193:1163.
PMID: 25463993