prostasin; serine protease 8 [contains: prostasin light chain & prostasin heavy chain] (PRSS8)

Function: - possesses a trypsin-like cleavage specificity Structure: - heterodimer of two chains, light & heavy, held by a disulfide bond - belongs to the peptidase S1 family - contains 1 peptidase S1 domain Compartment: - prostasin: cell membrane - prostasin light chain & prostasin heavy chain a) secreted, extracellular space b) secreted after cleavage of its C-terminus n) found in the seminal fluid Expression: - found in prostate, liver, salivary gland, kidney, lung, pancreas, colon, bronchus & renal proximal tubular cells - in prostate, it may be synthesized in epithelial cells, secreted into the ducts, & excreted into the seminal fluid

General

glycoprotein membrane protein serine protease trypsin family

Properties

SIZE: entity length = 343 aa MW = 36 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-29} cysteine residue {C37} MODIFICATION: cysteine residue {C-INTERCHAIN} S1 domain {45-286} MOTIF: cysteine residue {C70} MODIFICATION: cysteine residue {C86} histidine residue {H85} cysteine residue {C86} MODIFICATION: cysteine residue {C70} aspartate residue {D134} N-glycosylation site {N159} cysteine residue {C168} MODIFICATION: cysteine residue {C244} cysteine residue {C201} MODIFICATION: cysteine residue {C223} cysteine residue {C223} MODIFICATION: cysteine residue {C201} cysteine residue {C234} MODIFICATION: cysteine residue {C262} serine residue {S238} cysteine residue {C244} MODIFICATION: cysteine residue {C168} cysteine residue {C262} MODIFICATION: cysteine residue {C234} transmembrane domain {320-340}

Database Correlations

OMIM 600823 UniProt Q16651 Pfam PF00089 Entrez Gene 5652 Kegg hsa:5652

References

UniProt :accession Q16651