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prostaglandin F2 receptor negative regulator; CD9 partner 1; CD9P-1; Glu-Trp-Ile EWI motif-containing protein F; EWI-F; prostaglandin F2-alpha receptor regulatory protein; prostaglandin F2-alpha receptor-associated protein; CD315 (PTGFRN, CD9P1, EWIF, FPRP, KIAA1436)
Function:
- inhibits binding of PGF2-alpha to its specific receptor
- functional coupling with the prostaglandin F2-alpha receptor seems to occur
- interacts with CD9, CD81, CD63, CD82 & CD151
Structure:
- contains 6 Ig-like C2-type domains
Compartment:
- endoplasmic reticulum membrane
- Golgi, trans-Golgi network membrane
- single-pass type 1 membrane protein (putative)
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
phosphoprotein
Properties
SIZE: entity length = 879 aa
MW = 99 kD
COMPARTMENT: golgi
endoplasmic reticulum
MOTIF: signal sequence {1-25}
immunoglobulin superfamily domain {26-129}
MOTIF: cysteine residue {C43}
MODIFICATION: cysteine residue {C119}
N-glycosylation site {N44}
cysteine residue {C119}
MODIFICATION: cysteine residue {C43}
immunoglobulin superfamily domain {149-268}
MOTIF: cysteine residue {C169}
MODIFICATION: cysteine residue {C247}
cysteine residue {C247}
MODIFICATION: cysteine residue {C169}
immunoglobulin superfamily domain {276-394}
MOTIF: N-glycosylation site {N286}
cysteine residue {C299}
MODIFICATION: cysteine residue {C373}
N-glycosylation site {N300}
cysteine residue {C373}
MODIFICATION: cysteine residue {C299}
N-glycosylation site {N383}
immunoglobulin superfamily domain {406-536}
MOTIF: N-glycosylation site {N413}
Endoplasmic reticulum retention signal {424-427}
cysteine residue {C429}
MODIFICATION: cysteine residue {C515}
cysteine residue {C515}
MODIFICATION: cysteine residue {C429}
N-glycosylation site {N525}
immunoglobulin superfamily domain {544-662}
MOTIF: cysteine residue {C571}
MODIFICATION: cysteine residue {C655}
N-glycosylation site {N600}
N-glycosylation site {N618}
cysteine residue {C655}
MODIFICATION: cysteine residue {C571}
immunoglobulin superfamily domain {688-813}
MOTIF: N-glycosylation site {N691}
Cell attachment site {703-705}
cysteine residue {C711}
MODIFICATION: cysteine residue {C793}
cysteine residue {C793}
MODIFICATION: cysteine residue {C711}
transmembrane domain {833-853}
Ser phosphorylation site {S875}
Database Correlations
OMIM 601204
UniProt Q9P2B2
Pfam PF07686
Entrez Gene 5738
Kegg hsa:5738
References
UniProt :accession Q9P2B2