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prostaglandin E2 receptor EP1 subtype; prostanoid EP1 receptor; PGE receptor, EP1 subtype (PTGER1)
Function:
- receptor for prostaglandin E2 (PGE2)
- activity is mediated by G(q) proteins which activate a phosphatidylinositol-Ca+2 second messenger system
- may play a role as an important modulator of renal function
- implicated the smooth muscle contractile response to PGE2 in various tissues
- phosphorylated (putative)
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
Expression:
- abundant in kidney
- lower level expression in lung, skeletal muscle & spleen, lowest expression in testis
- not detected in liver brain & heart
General
glycoprotein
prostaglandin-E [PGE] receptor
Properties
SIZE: entity length = 402 aa
MW = 42 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-35}
MOTIF: N-glycosylation site {N8}
N-glycosylation site {N25}
transmembrane domain {36-62}
cytoplasmic loop {63-72}
transmembrane domain {73-96}
exoplasmic loop {97-111}
MOTIF: cysteine residue {C110}
MODIFICATION: cysteine residue {C188}
transmembrane domain {112-133}
cytoplasmic loop {134-155}
transmembrane domain {156-177}
exoplasmic loop {178-201}
MOTIF: cysteine residue {C188}
MODIFICATION: cysteine residue {C110}
transmembrane domain {202-227}
cytoplasmic loop {228-294}
transmembrane domain {295-321}
exoplasmic loop {322-332}
transmembrane domain {333-354}
cytoplasmic domain {355-402}
Database Correlations
OMIM 176802
UniProt P34995
Pfam PF00001
Entrez Gene 5731
Kegg hsa:5731
References
UniProt :accession P34995