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prostaglandin E2 receptor EP4 subtype; PGE receptor, EP4 subtype; prostanoid EP4 receptor (PTGER4, PTGER2)
Function:
- receptor for prostaglandin E2 (PGE2)
- activity is mediated by Gs proteins that stimulate adenylate cyclase
- has a relaxing effect on smooth muscle
- may play a role in
a) regulating renal hemodynamics
b) intestinal epithelial transport
c) adrenal aldosterone secretion
d) uterine function
- interacts with FEM1A
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
Expression:
- high expression in intestine & in peripheral blood mononuclear cells
- low expression in lung, kidney, thymus, uterus, vasculature & brain
- not found in liver, heart, retina or skeletal muscle
Note: Was originally designated as the EP2 subtype
General
glycoprotein
prostaglandin-E [PGE] receptor
Properties
SIZE: entity length = 488 aa
MW = 53 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-19}
MOTIF: N-glycosylation site {N7}
transmembrane domain {20-43}
cytoplasmic loop {44-55}
transmembrane domain {56-79}
exoplasmic loop {80-96}
MOTIF: cysteine residue {C92}
MODIFICATION: cysteine residue {C170}
transmembrane domain {97-115}
cytoplasmic loop {116-135}
transmembrane domain {136-160}
exoplasmic loop {161-184}
MOTIF: cysteine residue {C170}
MODIFICATION: cysteine residue {C92}
transmembrane domain {185-211}
cytoplasmic loop {212-267}
MOTIF: alanine-rich region {230-234}
MOTIF: alanine residue (SEVERAL)
transmembrane domain {268-295}
exoplasmic loop {296-312}
transmembrane domain {313-332}
cytoplasmic domain {333-488}
Database Correlations
OMIM 601586
UniProt P35408
Pfam PF00001
Entrez Gene 5734
Kegg hsa:5734
References
- UniProt :accession P35408
- SeattleSNPs
http://pga.gs.washington.edu/data/ptger4/