prostaglandin E2 receptor EP2 subtype; prostanoid EP2 receptor; PGE receptor, EP2 subtype (PTGER2)

Function: - receptor for prostaglandin E2 (PGE2) - activity is mediated by Gs proteins that stimulate adenylate cyclase - increase in intracellular cAMP mediates relaxing effect of PTGER2 on smooth muscle Structure: belongs to the G-protein coupled receptor 1 family Compartment: cell membrane Expression: placenta & lung

General

glycoprotein prostaglandin-E [PGE] receptor

Properties

SIZE: entity length = 358 aa MW = 40 kD COMPARTMENT: cellular membrane MOTIF: exoplasmic domain {1-23} MOTIF: N-glycosylation site {N3} N-glycosylation site {N6} transmembrane domain {24-47} cytoplasmic loop {48-65} transmembrane domain {66-91} exoplasmic loop {92-111} MOTIF: N-glycosylation site {N96} cysteine residue {C109} MODIFICATION: cysteine residue {C187} transmembrane domain {112-132} cytoplasmic loop {133-151} transmembrane domain {152-176} exoplasmic loop {177-198} MOTIF: cysteine residue {C187} MODIFICATION: cysteine residue {C109} transmembrane domain {199-223} cytoplasmic loop {224-262} transmembrane domain {263-286} exoplasmic loop {287-299} MOTIF: N-glycosylation site {N287} transmembrane domain {300-323} cytoplasmic domain {324-358}

Database Correlations

OMIM 176804 UniProt P43116 Pfam PF00001 Entrez Gene 5732 Kegg hsa:5732