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prostacyclin synthase; prostaglandin I2 synthase (PTGIS, CYP8, CYP8A1)
Function:
- catalyzes isomerization of prostaglandin H2 to prostacyclin (prostaglandin I2)
Cofactor: heme group (putative)
Structure: belongs to the cytochrome P450 family
Compartment:
- endoplasmic reticulum membrane
Expression:
- widely expressed
- particularly abundant in ovary, heart, skeletal muscle, lung & prostate
General
isomerase
membrane protein
Properties
SIZE: entity length = 500 aa
MW = 57 kD
COMPARTMENT: endoplasmic reticulum
MOTIF: transmembrane domain {1-20}
Iron [Fe]-binding site
SITE: 441-441
Database Correlations
OMIM 601699
UniProt Q16647
Pfam PF00067
Entrez Gene 5740
Kegg hsa:5740
ENZYME 5.3.99.4
References
- UniProt :accession Q16647
- Cytochrome P450 allele Nomenclature committee
Note: CYP8A1 alleles
http://www.cypalleles.ki.se/cyp8a1.htm