prosalusin (torsin-2A, torsin family 2 member A, [Contains: Salusin-alpha; Salusin-beta], TOR2A)

Function: - salusin-alpha & salusin-beta are produced by proteolytic processing of prosalusin - salusin-alpha & salusin-beta may be endocrine &/or paracrine factors able to increase intracellular Ca⁺² & induce cell mitogenesis - salusins may also be potent hypotensive peptides - amidation of salusin-alpha(29-Gly) by peptidylglycine alpha- amidating monooxygenase, PAM, converts Lys-241-Gly-242 to Lys-241-NH2 & gives raise to salusin-alpha - salusin-alpha & salusin-beta are only produced from an alternatively spliced mRNA of TOR2A, isoform 4 Structure: - belongs to the clpA/clpB family, torsin subfamily Compartment: secreted Alternative splicing: named isoforms=5 Expression: - isoform 4 is ubiquitously expressed, with high level in vascular endothelial cells & vascular smooth muscle cells See 2 different UniProt Entries

General

glycoprotein protein precursor

Properties

SIZE: MW = 26 kD entity length = 242 aa MOTIF: signal sequence {1-26} ATP-binding site NAME: ATP-binding site SITE: 93-100 N-glycosylation site {N149}

Database Correlations

OMIM 608052 SWISS-PROT correlations Pfam PF06309

References

UniProt :accession Q8N2E6, Q5JU69