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Proquad (measles, mumps, rubella [MMR] plus varicella viruses live, MMRV)

Indications: 1) immunization of children 4-12* years of age 2) may be used if 2nd dose of MMR is to be administered Contraindications: - infants 1-2 years of age* Adverse effects: - febrile seizures* [3] * CDC recommends that MMR vaccine be given separate from varicella vaccine at 1-2 years of age due to risk of febrile seizures * at 4-6 years of age the risk of febrile seizures has resolved [4] Mechanism of action: - attenuated live virus vaccine that combines measles, mumps, rubella & varicella viruses

Related

measles, mumps & rubella combined vaccine (MMR)

General

live virus vaccine

References

  1. Monthly Prescribing Reference http://www.PrescribingReference.com
  2. Shinefield H et al, Evaluation of quadrivalent measles, mumps, rubella and varicella vaccine in healthy children Pediatric Infect Dis J 2005; 24:665 PMID: 16094217
  3. Marin M, Broder KR, Temte JL, Snider DE, Seward JF, Centers for Disease Control and Prevention (CDC). Use of combination measles, mumps, rubella, and varicella vaccine: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 2010 May 7;59(RR-3):1-12. PMID: 20448530 corresponding NGC guideline withdrawn Jan 2016
  4. Klein NP et al Measles-Containing Vaccines and Febrile Seizures in Children Age 4 to 6 Years Pediatrics April 2, 2012 PMID: 22473362 http://pediatrics.aappublications.org/content/early/2012/03/28/peds.2011-3198.abstract