proprotein convertase PC4 (proprotein convertase subtilisin/kexin type 4, PCSK4, PC4, UNQ2757/PRO6496)

Function: 1) role in processing of hormone & other protein precursors at sites of pairs of basic amino acid residues 2) role in transcriptional coactivation 3) role ion stabilizing the multiprotein transcription complex (putative) Structure: 1) belongs to the peptidase S8 family, Furin subfamily 2) contains 1 FU repeat (furin-like repeat) Compartment: membrane Alternative splicing: named isoforms=2 Expression: - expressed in placenta - localized predominantly in the cytotrophoblast layer of trophoblast cells during the 1st trimester of pregnancy & to the syncytiotrophoblast & stroma cells during the 3rd trimester

General

glycoprotein membrane protein serine protease

Properties

SIZE: MW = 83 kD entity length = 755 aa COMPARTMENT: cellular membrane MOTIF: signal sequence {1-25} active site SITE: 124-417 MOTIF: aspartate residue {D158} histidine residue {H199} serine residue {S373} N-glycosylation site {N475} N-glycosylation site {N629} FU {646-694} transmembrane domain {709-729}

Database Correlations

OMIM 600487 UniProt Q6UW60 PFAM correlations

References

UniProt :accession Q6UW60