Search
proparacaine ophthalmic (Ophthaine, Ophthetic, Keracaine)
Tradenames: Ophthaine, Ophthetic.
Indications:
1) anesthesia for tonometry, gonioscopy, suture removal from cornea
2) removal of corneal foreign body, cataracts extraction, glaucoma surgery, short operative procedures involving the cornea & conjunctiva
Never prescribe due to corneal toxicity with repeated use.
Dosage:
1) ophthalmic surgery: 1 drop 0.05% solution every 5-10 minutes for total of 5-7 doses
2) tonometry, gonioscopy, suture removal: 1-2 drops of 0.o5% solution in eye just prior to the procedure
Solution: 0.05% (15 mL).
Adverse effects:
1) less common (1-10%)
- burning, stinging, redness
2) uncommon (< 1%)
- CNS depression, blurred vision, arrhythmias, increased sweating, lacrimation, allergic contact dermatitis, irritation, sensitization, keratitis, iritis, erosion of corneal epithelium, conjunctival congestion & hemorrhage, corneal opacification
General
proparacaine; proxymetacaine
ophthalmic anesthetic
Properties
MISC-INFO: pregnancy-category C
safety in lactation ?
Database Correlations
PUBCHEM correlations
References
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- Kaiser Permanente Northern California Regional Drug
Formulary, 1998