prominin-2 (PROM-2, prominin-like protein 2, hPROML2, PROM2, PROML2, UNQ2521/PRO6014)

Function: - binds cholesterol (putative) Structure: - glycosylated (putative) - belongs to the prominin family Compartment: - apical cell membrane - basolateral cell membrane (putative) - cell projection, microvillus membrane - cell projection, cilium - colocalizes with PROM1 - associates with membrane (cholesterol-dependent) - localizes to the apical & basolateral membranes of epithelial cells (putative) Alternative splicing: named isoforms=3 Expression: - present in saliva within small membrane particles (at protein level) - expressed in kidney, prostate, trachea, esophagus, salivary gland, thyroid gland, mammary gland, adrenal gland, placenta, stomach, spinal cord & liver. - in submucosal tumor, expressed in spindle-shaped or stellate stromal cells Pathology: - expressed in prostate cancer cell lines

General

glycoprotein transmembrane 5 protein

Properties

SIZE: entity length = 834 aa MW = 92 kD COMPARTMENT: cellular membrane MOTIF: exoplasmic domain {1-106} MOTIF: signal sequence {1-26} transmembrane domain {107-127} cytoplasmic loop {128-153} transmembrane domain {154-174} exoplasmic loop {175-426} MOTIF: N-glycosylation site {N270} transmembrane domain {427-447} cytoplasmic loop {448-472} transmembrane domain {473-493} exoplasmic loop {494-779} transmembrane domain {780-800} cytoplasmic domain {801-834}

Database Correlations

UniProt Q8N271 Pfam PF05478 Kegg hsa:1506

References

UniProt :accession Q8N271