proline-rich nuclear receptor coactivator 2 (PNRC2)

Function: - role in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex & the NMD machinery - may act by targeting the NMD machinery to the P-body & recruiting the decapping machinery to aberrant mRNAs - required for UPF1/RENT1 localization to the P-body - also acts as a nuclear receptor coactivator - may play a role in controlling the energy balance between energy storage & energy expenditure - interacts with UPF1/RENT1 - preferentially interacts with hyperphosphorylated form - interacts with DCP1A - interacts with many nuclear receptors including ESR1, ESRRA, ESRRG, NR3C1/GR, NR5A1, PGR, TR, RAR & RXR Structure: - the interaction between PNRC2 & nuclear receptors is dependent on the SH3 binding motif - belongs to the PNRC family, PNRC2 subfamily Compartment: - nucleus, cytoplasm, P-body Alternative splicing: named isoforms=2 Expression: - expressed in heart, lung, muscle, brain

Properties

SIZE: MW = 16 kD entity length = 139 aa COMPARTMENT: cell nucleus MOTIF: SH3-binding site NAME: SH3-binding site SITE: 99-105

Database Correlations

OMIM 611882 UniProt Q9NPJ4 LOCUS-LINK correlations Kegg hsa:55629

References

UniProt :accession Q9NPJ4