proline-rich nuclear receptor coactivator 1; proline-rich protein 2; B4-2 protein (PNRC1, PROL2)

Function: 1) nuclear receptor coactivator 2) signal transduction 3) interacts with many nuclear receptors including: AR, ESR1, ESRRA, ESRRG, NR3C1/GR, NR5A1/SF1, PGR, TR, RAR, RXR 4) interacts with GRB2 Structure: - interaction between PNRC1 & nuclear receptors is dependent on the SH3 binding motif - belongs to the PNRC family, PNRC1 subfamily Compartment: nucleus Expression: - expressed in liver, lung, fat, NK cell, T cells

General

proline-rich protein transcriptional adaptor protein; transcriptional coactivator

Properties

SIZE: MW = 35 kD entity length = 327 aa COMPARTMENT: cell nucleus MOTIF: nuclear translocation signal {94-101} proline-rich region SH3-binding site NAME: SH3-binding site SITE: 285-291

Database Correlations

OMIM 606714 UniProt Q12796 Entrez Gene 10957 Kegg hsa:10957

References

UniProt :accession Q12796