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proline-rich membrane anchor 1 (PRiMA) (PRIMA1)
Function:
- required to anchor acetylcholinesterase (ACHE) to the basal lamina of the neuromuscular junction & to the membrane of neuronal synapses in brain
- able to organize ACHE into tetramers (putative)
- interacts with ACHE, probably through disulfide bonds
Structure:
- proline-rich attachment domain (PRAD) binds the AChE catalytic subunits (putative)
- contains 1 PRAD domain (Pro-rich attachment domain)
Compartment: membrane
Alternative splicing: named isoforms=2
General
glycoprotein
membrane protein
Properties
SIZE: MW = 17 kD
entity length = 153 aa
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-35}
PRAD {56-70}
N-glycosylation site {N79}
transmembrane domain {93-113}
Database Correlations
UniProt Q86XR5
References
UniProt :accession Q86XR5