proline-rich acidic protein 1 (uterine-specific proline-rich acidic protein, PRAP1, UPA, UNQ608/PRO1195)

Function: - may play an important role in maintaining normal growth homeostasis in epithelial cells Compartment: secreted Alternative splicing: named isoforms=4 Expression: - abundantly expressed in epithelial cells of liver, kidney, gastrointestinal tract & cervix - up-regulated by butyrate, trichostatin A & 5'-aza-2' deoxycytidine Pathology: - significantly down-regulated in hepatocellular carcinoma & right colon adenocarcinoma compared with the respective adjacent normal tissues

Properties

SIZE: entity length = 151 aa MW = 17 kD COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-20}

References

UniProt :accession Q96NZ9