prolargin (proline-arginine-rich end leucine-rich repeat protein, PRELP)

Function: 1) anchors basement membranes to underlying connective tissue (putative) 2) binds basement membrane heparan sulfate proteoglycan perlecan & triple helical collagen type 1 & collagen type 2 via LRR Structure: - contains 12 LRR (leucine-rich) repeats Compartment: secreted, extracellular matrix Expression: expressed in connective tissue

General

glycoprotein secreted protein

Properties

SIZE: MW = 44 kD entity length = 382 aa COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-20} cysteine-rich region {73-89} leucine-rich repeat SITE: 95-114 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 115-138 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N124} leucine-rich repeat SITE: 139-162 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 163-183 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 184-207 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 208-233 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 234-254 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 255-278 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 279-303 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N289} leucine-rich repeat SITE: 304-323 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N320} leucine-rich repeat SITE: 324-362 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N327} cysteine residue {C332} MODIFICATION: cysteine residue {C373} leucine-rich repeat SITE: 363-382 MOTIF: leucine residue (SEVERAL) cysteine residue {C373} MODIFICATION: cysteine residue {C332}

Database Correlations

OMIM 601914 UniProt P51888 PFAM correlations

References

UniProt :accession P51888