prolactin regulatory element-binding protein; mammalian guanine nucleotide exchange factor msec12 (PREB, SEC12)

Function: - first identified based on its probable role in the regulation of pituitary gene transcription - binds to the prolactin gene promoter & seems to activate transcription - guanine nucleotide exchange factor that activates SARA2 - required for the formation of COP2 transport vesicles from the ER - binds SARA2 Structure: contains 3 WD repeats Compartment: - nucleus (putative) - endoplasmic reticulum membrane - single-pass membrane protein (putative) Expression: ubiquitous

General

guanine nucleotide exchange factor (GDP/GTP dissociation stimulator, guanine nucleotide-releasing factor/protein, GNEF, GNDS, GDS) membrane protein transcription factor (TF) WD repeat protein family

Properties

SIZE: entity length = 417 aa MW = 45 kD COMPARTMENT: cell nucleus MOTIF: WD repeat {152-191} WD repeat {194-232} WD repeat {298-337} transmembrane domain {389-409}

Database Correlations

OMIM 606395 UniProt Q9HCU5 Pfam PF00400 Entrez Gene 10113 Kegg hsa:10113

References

UniProt :accession Q9HCU5