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prolactin receptor; PRL-R (PRLR)
Function:
- receptor for prolactin
- isoforms 4 & 6 are unable to transduce prolactin signaling
- interacts with SMARCA1
- interacts with GH1
Structure:
- the WSXWS motif essential for
a) proper protein folding
b) efficient intracellular transport
c) cell-surface receptor binding
- box 1 motif is required for JAK interaction &/or activation
- belongs to the type 1 cytokine receptor family, type 1 subfamily
- contains 2 fibronectin F3 modules
Compartment: membrane, secreted
Alternative splicing:
1) named isoforms=8
2) soluble isoform that appears specific for the BT-474 breast cancer cell line
Expression:
- expressed in breast, placenta, kidney, liver & pancreas
General
glycoprotein
membrane protein
receptor
Properties
SIZE: entity length = 622 aa
MW = 70 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-24}
fibronectin type III domain or F3 module {27-121}
MOTIF: cysteine residue {C36}
MODIFICATION: cysteine residue {C46}
cysteine residue {C46}
MODIFICATION: cysteine residue {C36}
N-glycosylation site {N59}
cysteine residue {C75}
MODIFICATION: cysteine residue {C86}
cysteine residue {C86}
MODIFICATION: cysteine residue {C75}
N-glycosylation site {N104}
fibronectin type III domain or F3 module {127-227}
MOTIF: WSXWS motif {215-219}
N-glycosylation site {N233}
transmembrane domain {235-258}
box1 motif
SITE: 267-275
FOR-BINDING-OF: Janus kinase (JAK)
Database Correlations
OMIM 176761
UniProt P16471
Pfam PF00041
Entrez Gene 5618
Kegg hsa:5618
References
- UniProt :accession P16471
- Atlas of genetics & cytogenetics in oncology & haematology
http://atlasgeneticsoncology.org/genes/PRLRID42891ch5p14.html