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prokineticin receptor 2; PK-R2; G protein-coupled receptor 73-like 1 (PROKR2, GPR73b, GPRg2, GPR73L1, PKR2)
Function:
- receptor for prokineticin 2
- exclusively coupled to Gq proteins
- activation leads to mobilization of Ca+2, stimulation of phosphoinositide turnover & activation of p44/p42 mitogen-activated protein kinase
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
Expression:
- expressed in the ileocecum, thyroid gland, pituitary gland, salivary gland, adrenal gland, testis, ovary & brain
Pathology:
- defects in PROKR2 are the cause of Kallmann syndrome type 3
General
glycoprotein
G-protein coupled receptor; serpentine receptor
Properties
SIZE: MW = 44 kD
entity length = 384 aa
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-54}
MOTIF: N-glycosylation site {N7}
N-glycosylation site {N27}
transmembrane domain {55-75}
cytoplasmic loop {76-89}
transmembrane domain {90-110}
exoplasmic loop {111-136}
MOTIF: cysteine residue {C128}
MODIFICATION: cysteine residue {C208}
transmembrane domain {137-157}
cytoplasmic loop {158-171}
transmembrane domain {172-192}
exoplasmic loop {193-223}
MOTIF: cysteine residue {C208}
MODIFICATION: cysteine residue {C128}
transmembrane domain {224-244}
cytoplasmic loop {245-273}
transmembrane domain {274-294}
exoplasmic loop {295-313}
transmembrane domain {314-334}
cytoplasmic domain {335-384}
Database Correlations
OMIM correlations
MORBIDMAP 607123
UniProt Q8NFJ6
Pfam PF00001
Kegg hsa:1286
References
- UniProt :accession Q8NFJ6
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=PROKR2