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prokineticin-2 (PK2, protein Bv8 homolog, PROK2, BV8)
Function:
1) output molecule from the suprachiasmatic nucleus (SCN) that transmits behavioral circadian rhythm
2) role locally within the SCN to synchronize output
3) contracts gastrointestinal (GI) smooth muscle
Structure:
- belongs to the AVIT (prokineticin) family
Compartment: secreted
Alternative splicing: named isoforms=2
Expression:
- expressed in the testis > small intestine
- activated by CLOCK & BMAL1 heterodimers & light
- inhibited by period genes (PER1, PER2 & PER3) & cryptochrome genes (CRY1 & CRY2)
Related
suprachiasmatic nucleus
General
secreted protein
Properties
SIZE: MW = 14 kD
entity length = 129 aa
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-27}
cysteine residue {C34}
MODIFICATION: cysteine residue {C46}
cysteine residue {C40}
MODIFICATION: cysteine residue {C58}
cysteine residue {C45}
MODIFICATION: cysteine residue {C107}
cysteine residue {C46}
MODIFICATION: cysteine residue {C34}
cysteine residue {C58}
MODIFICATION: cysteine residue {C40}
cysteine residue {C68}
MODIFICATION: cysteine residue {C115}
cysteine residue {C107}
MODIFICATION: cysteine residue {C45}
cysteine residue {C109}
MODIFICATION: cysteine residue {C125}
cysteine residue {C115}
MODIFICATION: cysteine residue {C68}
cysteine residue {C125}
MODIFICATION: cysteine residue {C109}
Database Correlations
OMIM 607002
MORBIDMAP 607002
UniProt Q9HC23
Pfam PF06607
References
UniProt :accession Q9HC23