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prokineticin-1 (endocrine-gland-derived vascular endothelial growth factor, EG-VEGF, mambakine, PROK1)
Function:
1) contracts gastrointestinal (GI) smooth muscle
2) induces proliferation, migration & fenestration in capillary endothelial cells derived from endocrine glands
3) little or no effect on other endothelial & non-endothelial cells
Compartment: secreted
Expression:
- expressed in the steroidogenic glands, ovary, testis, adrenal, placenta
General
secreted protein
Properties
SIZE: MW = 12 kD
entity length = 105 aa
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-19}
cysteine residue {C26}
MODIFICATION: cysteine residue {C38}
cysteine residue {C32}
MODIFICATION: cysteine residue {C50}
cysteine residue {C37}
MODIFICATION: cysteine residue {C78}
cysteine residue {C38}
MODIFICATION: cysteine residue {C26}
cysteine residue {C50}
MODIFICATION: cysteine residue {C32}
cysteine residue {C60}
MODIFICATION: cysteine residue {C86}
cysteine residue {C78}
MODIFICATION: cysteine residue {C37}
cysteine residue {C80}
MODIFICATION: cysteine residue {C96}
cysteine residue {C86}
MODIFICATION: cysteine residue {C60}
cysteine residue {C96}
MODIFICATION: cysteine residue {C80}
Database Correlations
OMIM 606233
UniProt P58294
Pfam PF06607
References
UniProt :accession P58294