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proprotein convertase PC7 (proprotein convertase subtilisin/kexin type 7, subtilisin/kexin-like protease PC7, prohormone convertase PC7, PC8, hPC8, lymphoma proprotein convertase)
Function:
- ubiquitous endoprotease activity within constitutive secretory pathways (putative)
- capable of cleavage at the RXXX[KR]R consensus motif
- inhibited by Zn+2 & copper (putative)
- release of mature proteins from their proproteins by cleavage of Arg-Xaa-Xaa-Xaa-Yaa-Arg-|-Zaa bonds, where Xaa can be any amino acid & Yaa is Arg or Lys
Cofactor: Ca+2 (putative)
Structure:
- Cys in the cytoplasmic tail are probably palmitoylated
- N-glycosylated
- belongs to the peptidase S8 family
- contains 1 homo B/P domain
Compartment:
- Golgi, trans-Golgi network membrane
- seems to be localized intracellularly to the trans Golgi network (putative)
Expression:
- expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon & peripheral blood leukocytes
General
glycoprotein
membrane protein
subtilase (serine protease subtilisin family, subtilisin/kexin-like protease)
Properties
SIZE: entity length = 785 aa
MW = 86 kD
COMPARTMENT: golgi
MOTIF: signal sequence {1-37}
proteolytic site {141-142}
active site
SITE: 142-474
MOTIF: N-glycosylation site {N167}
N-glycosylation site {N175}
aspartate residue {D187}
histidine residue {H228}
N-glycosylation site {N241}
serine residue {S406}
Homo B/P {482-617}
MOTIF: N-glycosylation site {N511}
transmembrane domain {668-688}
Database Correlations
OMIM 604872
UniProt Q16549
PFAM correlations
References
- PROSITE :acccesion Q16549
- UniProt :accession Q16549