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proprotein convertase PC5 (proprotein convertase subtilisin/kexin type 5, subtilisin/kexin-like protease PC5, prohormone convertase PC5, PC6, hPC6)
Function:
- widespread endoprotease activity within constitutive & regulated secretory pathway (putative)
- capable of cleavage at the RX(K/R)R consensus motif
- release of mature proteins from their proproteins by cleavage of Arg-Xaa-Yaa-Arg-|-Zaa bonds, where Xaa can be any amino acid & Yaa is Arg or Lys
Structure:
- propeptide domain acts as an intramolecular chaperone assisting folding of zymogen within the endoplasmic reticulum
- belongs to the peptidase S8 family
- contains 1 homo B/P domain
- contains 1 PLAC domain
Compartment: secreted (putative)
Alternative splicing: named isoforms=1
2 isoforms may be produced
Expression: expressed in T-lymphocytes
General
glycoprotein
subtilase (serine protease subtilisin family, subtilisin/kexin-like protease)
Properties
SIZE: entity length = 913 aa
MW = 102 kD
MOTIF: signal sequence {1-32}
proteolytic site {114-115}
active site
SITE: 115-454
MOTIF: aspartate residue {D171}
histidine residue {H212}
N-glycosylation site {N225}
N-glycosylation site {N381}
serine residue {S386}
Homo B/P {462-600}
MOTIF: Cell attachment site {519-521}
CRM (Cys-rich motif) {636-868}
MOTIF: N-glycosylation site {N665}
N-glycosylation site {N752}
N-glycosylation site {N802}
N-glycosylation site {N852}
PLAC {869-913}
Database Correlations
OMIM 600488
UniProt Q92824
PFAM correlations
References
- PROSITE :acccesion Q92824
- UniProt :accession Q92824