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progressive pseudorheumatoid arthropathy of childhood
Pathology:
- primary disorder of articular cartilage
- continued cartilage loss & destructive bone changes
Genetics:
- autosomal recessive
- associated with defects in WISP3
Clinical manifestations:
- stiffness & swelling of joints
- muscle weakness
- joint contractures
- signs & symptoms generally develop 3-8 years of age
General
genetic disease of bone/skeletal system
genetic disease of muscle (inherited myopathy)
Database Correlations
OMIM 208230
References
OMIM :accession 208230