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programmed cell death protein 6; apoptosis-linked gene 2 protein; Ca+2-binding protein ALG-2 (PDCD6, ALG2)
Function:
- Ca+2-binding protein required for T-cell receptor-, Fas-, & glucocorticoid-induced cell death
- may mediate Ca+2-regulated signals along the death pathway (putative)
- Ca+2-dependent adapter necessary for the association between PDCD6IP & TSG101
- self-associates (putative), homodimer
- interacts with PEF1
- interacts with RBM22
- interacts with PLSCR4, ANXA7 & TSG101
- interacts with SEC31A, PDCD6IP, & the N-termini of ANXA11 & PLSCR3 (Ca+2-dependent)
Structure: contains 5 EF-hand domains
Compartment:
- nuclear membrane; peripheral membrane
- endoplasmic reticulum membrane
- interaction with RBM22 induces relocalization from the cytoplasm to the nucleus
Related
apoptosis
programmed cell death 6-interacting protein; PDCD6-interacting protein; ALG-2 interacting protein 1; Hp95 (PDCD6IP, AIP1, KIAA1375)
programmed cell death protein
General
Ca+2 binding protein
nuclear protein
Properties
SIZE: entity length = 191 aa
MW = 22 kD
COMPARTMENT: cytoplasm
cell nucleus
endoplasmic reticulum
MOTIF: EF hand
SITE: 23-58
MOTIF: Ca+2-binding site
SITE: 36-47
EF hand
SITE: 59-89
MOTIF: Ca+2-binding site
SITE: 73-84
EF hand
SITE: 90-125
MOTIF: Ca+2-binding site
SITE: 103-114
EF hand
SITE: 126-161
EF hand
SITE: 162-191
MOTIF: Ca+2-binding site
SITE: 169-181
Database Correlations
OMIM 601057
UniProt O75340
Pfam PF00036
Entrez Gene 10016
Kegg hsa:10016
References
- UniProt :accession O75340
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/PDCD6ID43402ch5p15.html
Component-of
endosomal sorting complex required for transport-1 (ESCRT1)