programmed cell death protein 4; nuclear antigen H731-like; neoplastic transformation inhibitor protein; protein 197/15a (PDCD4, H731)

Function: 1) tumor suppressor protein 2) inhibits tumor promoter-induced neoplastic transformation 3) down-regulates expression of MAP4K1 inhibiting MAPK85 activation & consequent JUN-dependent transcription 4) role in apoptosis (putative) 5) inhibits helicase activity of EIF4A & cap-dependent translation 6) binds RNA 7) interacts with EIF4A1 & EIF4A2 - binds EIF4A1 via the MA3 domains Structure: 1) belongs to the PDCD4 family 2) contains 2 MA3 domains Compartment: - nucleus, cytoplasm - shuttles between the nucleus & cytoplasm - predominantly nuclear under normal growth conditions - exported from the nucleus in the absence of serum Expression: - up-regulated in proliferative cells - highly expressed in epithelial cells of the mammary gland - IL2 stimulation inhibits expression - IL12 increases expressio Pathology: - loss of expression correlated with tumor progression of lung cancer & colon carcinoma

General

nuclear protein phosphoprotein RNA-binding protein

Properties

SIZE: MW = 52 kD entity length = 469 aa COMPARTMENT: cytoplasm cell nucleus MOTIF: nuclear translocation signal {58-64} Thr phosphorylation site {T93} Tyr phosphorylation site {Y152} MA3 1 {164-275} MOTIF: nuclear translocation signal {241-250} MA3 2 {327-440} Ser phosphorylation site {S457}

Database Correlations

OMIM 608610 UniProt Q53EL6 Pfam PF02847 Entrez Gene 27250

References

UniProt :accession Q53EL6