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programmed cell death protein 11; protein RRP5 homolog; NF-kappa-B-binding protein; NFBP (PDCD11, KIAA0185)
Function:
- essential for the generation of mature 18S rRNA,
- specifically necessary for cleavages at sites A0, 1 & 2 of the 47S rRNA precursor
- directly interacts with U3 snoRNA
- role in the biogenesis of rRNA (putative)
- interacts with NF-kappa-B p50/NFKB1 & NF-kappa-B p65/RELA
Structure:
- contains 4 HAT repeats
- contains 12 S1 motif domains
Compartment: nucleus, nucleolus
Related
apoptosis
programmed cell death protein
General
nuclear protein
phosphoprotein
RNA-binding protein
Properties
SIZE: entity length = 1871 aa
MW = 209 kD
COMPARTMENT: cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Ser phosphorylation site {S7}
S1 domain {83-171}
S1 domain {187-258}
S1 domain {281-346}
S1 domain {365-436}
Thr phosphorylation site {T437}
Ser phosphorylation site {S438}
S1 domain {453-522}
S1 domain {542-611}
S1 domain {636-707}
S1 domain {729-798}
S1 domain {1036-1109}
S1 domain {1149-1222}
S1 domain {1230-1298}
S1 domain {1324-1396}
MOTIF: Ser phosphorylation site {S1360}
Ser phosphorylation site {S1454}
Ser phosphorylation site {S1493}
Ser phosphorylation site {S1498}
HAT {1599-1631}
HAT {1705-1737}
HAT {1775-1807}
HAT {1809-1844}
Database Correlations
OMIM 612333
UniProt Q14690
PFAM correlations
Entrez Gene 22984
Kegg hsa:22984
References
UniProt :accession Q14690