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programmed cell death protein 10; cerebral cavernous malformations 3 protein; TF-1 cell apoptosis-related protein 15 (PDCD10, CCM3, TFAR15)
Function:
- promotes cell proliferation
- modulates apoptotic pathways
- increases mitogen-activated protein kinase activity & MST4 activity
- important for cell migration, & for normal structure & assembly of the Golgi complex
- important for KDR/VEGFR2 signaling
- increases stability of KDR/VEGFR2 & prevents its breakdown
- required for normal cardiovascular development
- required for normal angiogenesis, vasculogenesis & hematopoiesis during embryonic development (putative)
- interacts (via C-terminus) with CCM2 & PXN
- interacts (via N-terminus) with MST4, STK24 & STK25
- interacts with GOLGA2
- identified in a complex with CCM1 & CCM2
- interacts with KDR/VEGFR2
- interaction with KDR/VEGFR2 is enhanced by stimulation with VEGFA (putative)
Structure:
- homodimer
- belongs to the PDCD10 family
Compartment:
- cytoplasm, Golgi membrane
- plasma membrane, cytoplasmic side
- partially co-localizes with endogenous PXN at the leading edges of migrating cells
Expression: ubiquitous
Pathology:
- defects in PDCD10 are the cause of cerebral cavernous malformations type 3
Related
apoptosis
PDCD10 gene mutation
programmed cell death protein
General
nuclear protein
RNA-binding protein
Properties
SIZE: entity length = 212 aa
MW = 25 kD
COMPARTMENT: cytoplasm
golgi
MOTIF: RNA-binding motif
FOR-BINDING-OF: ribonucleic acid
Database Correlations
OMIM correlations
UniProt Q9BUL8
Pfam PF06840
Entrez Gene 11235
Kegg hsa:11235
References
- UniProt :accession Q9BUL8
- GeneReviews
http://www.ncbi.nlm.nih.gov/sites/genetests/lab/gene/PDCD10