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Profilin-2; Profilin II (PFN2)
Function:
- binds to actin & affects structure of the cytoskeleton
- modulates polymerization of actin inhibits it at high but enhances it at low concentrations
- by binding to PIP2, inhibits formation of IP3 & diacylglycerol
- occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio
Structure: belongs to the profilin family
Compartment: cytoplasm, cytoskeleton
Alternative splicing: named isoforms=2
Expression:
- highly expressed in brain, skeletal muscle & kidney
- less strongly expressed in heart, placenta, lung & liver
General
profilin
Properties
SIZE: entity length = 140 aa
MW = 15 kD
COMPARTMENT: cytoplasm
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Tyr phosphorylation site {Y99}
Database Correlations
OMIM 176590
UniProt P35080
Pfam PF00235
Entrez Gene 5217
Kegg hsa:5217
References
- UniProt :accession P35080
- OMIM :accession 176590