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profilin-1; profilin I (PFN1)
Function:
- binds to actin & affects the structure of the cytoskeleton
- modulates polymerization of actin; inhibits high but enhances at low concentrations
- by binding to PIP2, inhibits formation of IP3 & diacylglycerol
- occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio
- found in a complex with XPO6, Ran, ACTB & PFN1
Structure: belongs to the profilin family
Compartment: cytoplasm, cytoskeleton
General
profilin
Properties
SIZE: entity length = 140 aa
MW = 15 kD
COMPARTMENT: cytoplasm
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Tyr phosphorylation site {Y129}
Database Correlations
OMIM 176610
UniProt P07737
Pfam PF00235
Entrez Gene 5216
Kegg hsa:5216
References
- UniProt :accession P07737
- OMIM :accession 176610