procollagen C-endopeptidase enhancer 2 (procollagen COOH-terminal proteinase enhancer 2, procollagen C-proteinase enhancer 2, PCPE-2, PCOLCE2, PCPE2, UNQ250/PRO287)

Function: - binds to the C-terminal propeptide of procollagen types 1 & 2 2) may enhance the cleavage of propeptide by BMP1 3) interacts with heparin with high affinity, collagen type 1 or collagen type 2 Structure: - O-glycosylated, contains sialic acid - contains 2 CUB domains - contains 1 NTR domain Compartment: secreted protein Expression: - expressed in the heart, trabecular meshwork, pituitary gland, bladder, mammary gland, trachea, placenta > brain - expressed in cartilage

General

glycoprotein secreted protein

Properties

SIZE: MW = 46 kD entity length = 415 aa COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-23} CUB domain {33-144} MOTIF: cysteine residue {C33} MODIFICATION: cysteine residue {C59} cysteine residue {C59} MODIFICATION: cysteine residue {C33} cysteine residue {C86} MODIFICATION: cysteine residue {C107} cysteine residue {C107} MODIFICATION: cysteine residue {C86} CUB domain {154-268} MOTIF: cysteine residue {C154} MODIFICATION: cysteine residue {C181} cysteine residue {C181} MODIFICATION: cysteine residue {C154} cysteine residue {C208} MODIFICATION: cysteine residue {C231} cysteine residue {C231} MODIFICATION: cysteine residue {C208} NTR {297-415} MOTIF: cysteine residue {C297} MODIFICATION: cysteine residue {C364} cysteine residue {C312} MODIFICATION: cysteine residue {C415} N-glycosylation site {N355} cysteine residue {C364} MODIFICATION: cysteine residue {C297} cysteine residue {C415} MODIFICATION: cysteine residue {C312}

Database Correlations

OMIM 607064 UniProt Q9UKZ9 PFAM correlations

References

UniProt :accession Q9UKZ9