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proapoptotic nucleolar protein 1 (PANO1, PANO)
Function:
- apoptosis-inducing protein
- modulates tumor suppressor function of CDKN2A/p14ARF
- enhances stability of CDKN2A/p14ARF by protecting it from degradation
- may act as a tumor suppressor
Compartment:
- nucleus, nucleolus
- colocalizes with CDKN2A/p14ARF in the nucleolus
Expression:
- widely expressed
- up-regulated after serum withdrawal
General
nuclear protein
Properties
SIZE: entity length = 215 aa
MW = 23 kD
COMPARTMENT: cell nucleus
MOTIF: proline-rich region
SITE: 66-180
MOTIF: proline residue (SEVERAL)
arginine-rich region {122-211}
MOTIF: arginine residue (SEVERAL)
domain {185-215}
Database Correlations
UniProt I0J062
Entrez Gene 101927
Kegg hsa:101927
References
- UniProt :accession I0J062
- PMID: 22094112