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PRKR-interacting protein 1 (PRKRIP1)
Function:
- binds double-stranded RNA
- inhibits EIF2AK2 kinase activity (putative)
- interacts with EIF2AK2 (putative)
Structure: belongs to the PRKRIP1 family
Compartment: nucleus, nucleolus (putative)
General
nuclear protein
phosphoprotein
RNA-binding protein
Properties
SIZE: entity length = 184 aa
MW = 21 kD
COMPARTMENT: cell nucleus
MOTIF: EIF2AK2 interaction {1-50}
RNA-BINDING-SITE
:SITE RANGE
:LOW 51
:HIGH 143
:ENGLISH "required for RNA binding"
coiled coil {91-152}
MOTIF: nuclear localization {126-138}
serine-rich region {162-165}
MOTIF: serine residue (SEVERAL)
Ser phosphorylation site {S162}
Ser phosphorylation site {S163}
Ser phosphorylation site {S164}
Ser phosphorylation site {S165}
Ser phosphorylation site {S169}
Thr phosphorylation site {T171}
glutamate-rich region {172-176}
MOTIF: glutamate residue (SEVERAL)
Database Correlations
UniProt Q9H875
Pfam PF06658
Kegg hsa:7970
References
UniProt :accession Q9H875