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prickle-like protein 2 (PRICKLE2)
Structure:
- prenylated on Cys-841
- contains 3 LIM zinc-binding domains
- contains 1 PET domain
Compartment: nuclear membrane
Expression:
- expressed in brain, eye, testis
- expressed in fetal brain, adult cartilage, pancreatic islet
Pathology:
- expressed in gastric cancer & uterus tumors
General
nuclear protein
prenyl protein
Properties
SIZE: MW = 96 kD
entity length = 844 aa
COMPARTMENT: nuclear membrane
MOTIF: LIM domain {128-193}
MOTIF: cysteine residue (6)
histidine residue
Zn+2-binding site
LIM domain {193-253}
MOTIF: cysteine residue (6)
histidine residue
Zn+2-binding site
LIM domain {253-317}
MOTIF: cysteine residue (6)
histidine residue
Zn+2-binding site
glutamate-rich region {504-510}
MOTIF: glutamate residue (SEVERAL)
arginine-rich region {668-730}
MOTIF: arginine residue (SEVERAL)
Ser phosphorylation site {S695}
serine-rich region {779-784}
MOTIF: serine residue (SEVERAL)
CaaX motif
SITE: C-TERMINUS
QUALITIES: AAX-TRUNCATED
CARBOXYMETHYLATED
EFFECTOR-BOUND: prenyl
BOUND-VIA: cysteine residue
Database Correlations
OMIM 608501
UniProt Q7Z3G6
PFAM correlations
References
UniProt :accession Q7Z3G6