pre T-cell antigen receptor alpha (pTa, pT-alpha, pT-alpha-TCR) (PTCRA)

Function: - component of pre-T-cell receptor complex - heterodimer with TCRB; disulfide linked - heterodimer assembles with CD3 proteins into a signaling-competent pre-T-cell receptor complex Compartment: membrane Alternative splicing: named isoforms=3 Expression: - expressed in immature but not mature T-cells - also found in CD34+ cells from peripheral blood, CD34+ precursors from umbilical cord blood & adult bone marrow - expressed in fetal life in CD34+ progenitors - present in the liver at 18 weeks of gestation but is absent in CD34+ precursors from fetal bone marrow at any developmental stage up to 22 weeks

General

glycoprotein membrane protein receptor

Properties

SIZE: entity length = 281 aa MW = 29 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-23} cysteine residue {C47} MODIFICATION: cysteine residue {C107} N-glycosylation site {N67} cysteine residue {C107} MODIFICATION: cysteine residue {C47} cysteine residue {C135} MODIFICATION: cysteine residue {C-INTERCHAIN} transmembrane domain {147-167}

Database Correlations

OMIM 606817 UniProt Q6ISU1 Kegg hsa:1715

References

UniProt :accession Q6ISU1