pre-mRNA-processing factor 40 homolog B (Huntingtin-interacting protein HYPC, Huntingtin yeast partner C, PRPF40B, HYPC)

Function: - may be involved in pre-mRNA splicing - interacts with the N-terminus of HD Structure: belongs to the PRPF40 family contains 2 FF domains contains 2 WW domains Compartment: nuclear speckle Alternative splicing: named isoforms=4 Expression: - expressed in the striatum & cortex of the brain (at protein level) - highly expressed in testis, fetal kidney & fetal brain - moderately expressed in pancreas, skeletal muscle, placenta, brain & heart - weakly expressed in colon, ileum, ovary, prostate, spleen, kidney & fetal lung

General

nuclear protein phosphoprotein

Properties

SIZE: entity length = 871 aa MW = 99 kD COMPARTMENT: cell nucleus MOTIF: proline-rich region SITE: 3-72 MOTIF: proline residue (SEVERAL) WW domain (W/rsp5/WWP domain) {92-125} WW domain (W/rsp5/WWP domain) {133-166} FF domain {278-327} FF domain {492-547} Ser phosphorylation site {S832}

Database Correlations

UniProt Q6NWY9 PFAM correlations

References

UniProt :accession Q6NWY9