Search
pre-mRNA cleavage complex 2 (pre mRNA 3' end processing complex)
Structure:
- consists of: CLP1, CPSF1, CPSF4, CSTF2, PCF11
General
molecular complex
Properties
COMPARTMENT: cell nucleus
SUBUNITS: pre-mRNA cleavage complex 2 protein Clp1
COMPARTMENT: cell nucleus
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 121-128
cleavage & polyadenylation specificity factor subunit 1
COMPARTMENT: cell nucleus
MOTIF: Thr phosphorylation site {T739}
nuclear translocation signal {893-908}
cleavage & polyadenylation specificity factor subunit 4
COMPARTMENT: cell nucleus
MOTIF: Zinc finger
NAME: Zinc finger
SITE: 35-61
EFFECTOR-BOUND: Zn+2
Zinc finger
NAME: Zinc finger
SITE: 62-89
EFFECTOR-BOUND: Zn+2
Zinc finger
NAME: Zinc finger
SITE: 90-117
EFFECTOR-BOUND: Zn+2
Zinc finger
NAME: Zinc finger
SITE: 118-142
EFFECTOR-BOUND: Zn+2
Zinc finger
NAME: Zinc finger
SITE: 143-169
EFFECTOR-BOUND: Zn+2
Ser phosphorylation site {S200}
Ser phosphorylation site {S202}
Ser phosphorylation site {S211}
Ser phosphorylation site {S212}
Zn finger C2HC-type
SITE: 243-260
EFFECTOR-BOUND: Zn+2
cleavage stimulation factor 64 kD subunit
COMPARTMENT: cell nucleus
MOTIF: RNP motif
NAME: RNP motif
SITE: 16-94
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
NAME: ribonucleoprotein-1 motif
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
ribonucleoprotein-2 motif
ribonucleoprotein-2 motif
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
ribonucleoprotein-2 motif
CSTF3/SYMPK interaction {108-248}
MOTIF: Ser phosphorylation site {S154}
proline-rich region
SITE: 198-409
MOTIF: proline residue (SEVERAL)
M-E-A-R-[AG] repeats {410-469}
MOTIF: consensus repeat {410-414}
consensus repeat {415-419}
consensus repeat {420-424}
consensus repeat {425-429}
consensus repeat {430-434}
consensus repeat {435-439}
consensus repeat {440-444}
consensus repeat {445-449}
consensus repeat {450-454}
consensus repeat {455-459}
consensus repeat {460-464}
consensus repeat {465-469}
proline-rich region
SITE: 470-526
MOTIF: proline residue (SEVERAL)
RPO2TC1 interaction {514-577}
MOTIF: Ser phosphorylation site {S518}
Ser phosphorylation site {S524}
pre-mRNA cleavage complex 2 protein Pcf11
COMPARTMENT: cell nucleus
MOTIF: arginine-rich region {38-41}
MOTIF: arginine residue (SEVERAL)
lysine-rich region {427-535}
MOTIF: lysine residue (SEVERAL)
glycine-rich region {802-1179}
MOTIF: glycine-rich region {898-901}
glycine-rich region {941-944}
glutamate-rich region {1403-1406}
MOTIF: glutamate residue (SEVERAL)
glutamate-rich region {1555-1559}
MOTIF: glutamate residue (SEVERAL)
Thr phosphorylation site {T1629}
References
UniProt :accession Q92989, O94913
Components
cleavage & polyadenylation specificity factor subunit 1; cleavage & polyadenylation specificity factor 160 kD subunit; CPSF 160 kD subunit (CPSF1, CPSF160)
cleavage & polyadenylation specificity factor subunit 4; cleavage & polyadenylation specificity factor 30 kD subunit; CPSF 30 kD subunit; NS1 effector domain-binding protein 1; Neb-1; No arches homolog (CPSF4 CPSF30 NAR NEB1)
cleavage stimulation factor 64 kD subunit; CSTF 64 kD subunit; CstF-64; CF-1 64 kD subunit (CSTF2)
pre-mRNA cleavage complex 2 protein Clp1 (CLP1, HEAB)
pre-mRNA cleavage complex 2 protein Pcf11 (PCF11, KIAA0824)