pre-mRNA 3'-end-processing factor FIP1 (FIP1-like 1, factor interacting with PAP, hFip1, rearranged in hypereosinophilia, FIP1L1, FIP1, RHE)

Function: 1) component of CPSF complex 2) FIP1L1 contributes to poly(A) site recognition 3) stimulates poly(A) addition 4) binds to U-richRNA sequence elements surrounding poly(A) site 5) tethers poly(A) polymerase to the CPSF complex (putative) Compartment: nucleus Alternative splicing: named isoforms=4 Pathology: 1) fusion of FIP1L1 & PDGFRA (FIP1L1-PDGFRA), due to an interstitial chromosomal deletion del(4)(q12q12), is the cause of some cases of hypereosinophilic syndrome

Properties

SIZE: MW = 67 kD entity length = 594 aa COMPARTMENT: cell nucleus MOTIF: PAPOLA {1-356} MOTIF: binding site SITE: 1-111 FOR-BINDING-OF: poly(A) polymerase alpha BINDING-STIE :SITE RANGE :LOW 137 :HIGH 243 :FOR_BINDING_OF CPSF4 Ser phosphorylation site {S259} proline-rich region SITE: 356-406 MOTIF: proline residue (SEVERAL) CPSF1/CSTF3 NAME: CPSF1/CSTF3 SITE: 443-594 FOR-BINDING-OF: cleavage & polyadenylation specificity factor subunit 1 cleavage stimulation factor 77 kD subunit MOTIF: arginine-rich region {456-562} MOTIF: arginine residue (SEVERAL) glutamate-rich region {478-594} MOTIF: glutamate residue (SEVERAL) Ser phosphorylation site {S554}

Database Correlations

OMIM correlations UniProt Q6UN15 Pfam PF05182

References

UniProt :accession Q6UN15