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pre-alpha-inhibitor (P-alpha-I)
Function:
- carrier of hyaluronan in serum (putative)
- binding protein between hyaluronan & other matrix proteins, including those on cell surfaces
- may regulate localization, synthesis & degradation of hyaluronan
Structure:
- subunits:
- ITIH3 & bikunin
- ITIH3 linked to bikunin via chondroitin 4-sulfate esterified to the ITIH3 alpha-carboxyl of C-terminal Asp after propeptide cleavage (putative)
General
molecular complex
plasma protein
protease inhibitor
Properties
COMPARTMENT: plasma
INHIBITS: protease
SUBUNITS: inter alpha antitrypsin heavy chain-3
MOTIF: signal sequence {1-17}
N-glycosylation site {N87}
VWFA domain {278-438}
N-glycosylation site {N576}
binding site
SITE: 647-647
FOR-BINDING-OF: chondroitin sulfate
alpha-1 microglobulin
MOTIF: signal sequence {1-19}
Thr glycosylation site {T24}
N-glycosylation site {N36}
cysteine residue {C91}
MODIFICATION: cysteine residue {C188}
N-glycosylation site {N115}
cysteine residue {C188}
MODIFICATION: cysteine residue {C91}
GLYCOPEPTIDE (SECRETORY) {206-226}
MOTIF: Ser glycosylation site {S215}
Kunitz-type serine protease inhibitor [KPI] domain {231-337} (2)
MOTIF: cysteine residue {C231}
MODIFICATION: cysteine residue {C281}
cysteine residue {C240}
MODIFICATION: cysteine residue {C264}
N-glycosylation site {N250}
cysteine residue {C256}
MODIFICATION: cysteine residue {C277}
cysteine residue {C264}
MODIFICATION: cysteine residue {C240}
cysteine residue {C277}
MODIFICATION: cysteine residue {C256}
cysteine residue {C281}
MODIFICATION: cysteine residue {C231}
FOR-BINDING-OF: serine protease
References
Uniprot :accession Q06033
Components
alpha-1 microglobulin; alpha-1 antitrypsin light chain; protein HC; bikunin (a lipocalin, AMBP, HCP, ITIL)
inter alpha antitrypsin heavy chain-3 (ITIH3, ITI heavy chain H3, inter-alpha-inhibitor heavy chain 3, serum-derived hyaluronan-associated protein, SHAP)