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prepro-vasopressin; vasopressin-neurophysin 2 copeptin (AVP)
Function:
- precursor for
- arginine vasopressin
- neurophysin 2
- neurophysin 2 specifically binds vasopressin
- copeptin
Structure: belongs to the vasopressin/oxytocin family
Compartment: secreted
Pathology:
- defects in AVP are the cause of
a) autosomal dominant neurohypophyseal diabetes insipidus
b) autosomal recessive neurohypophyseal diabetes insipidus
- disruption of preproAVP-NPII processing believed to play a role
Related
AVP, AVRP or VP (arginine-vasopressin) gene
General
glycoprotein
peptide precursor
protein precursor
Properties
SIZE: entity length = 164 aa
MW = 17 kD
MOTIF: signal sequence {1-19}
cysteine residue {C20}
MODIFICATION: cysteine residue {C25}
cysteine residue {C25}
MODIFICATION: cysteine residue {C20}
cysteine residue {C41}
MODIFICATION: cysteine residue {C85}
cysteine residue {C44}
MODIFICATION: cysteine residue {C58}
cysteine residue {C52}
MODIFICATION: cysteine residue {C75}
cysteine residue {C58}
MODIFICATION: cysteine residue {C44}
cysteine residue {C59}
MODIFICATION: cysteine residue {C65}
cysteine residue {C65}
MODIFICATION: cysteine residue {C59}
cysteine residue {C75}
MODIFICATION: cysteine residue {C52}
proteolytic site
cysteine residue {C85}
MODIFICATION: cysteine residue {C41}
cysteine residue {C92}
MODIFICATION: cysteine residue {C104}
cysteine residue {C98}
MODIFICATION: cysteine residue {C116}
cysteine residue {C104}
MODIFICATION: cysteine residue {C92}
cysteine residue {C105}
MODIFICATION: cysteine residue {C110}
cysteine residue {C110}
MODIFICATION: cysteine residue {C105}
cysteine residue {C116}
MODIFICATION: cysteine residue {C98}
N-glycosylation site {N131}
PRECURSOR-FOR: arginine vasopressin
neurophysin-2
Database Correlations
OMIM correlations
MORBIDMAP 192340
UniProt P01185
PFAM correlations
Entrez Gene 551
Kegg hsa:551
References
- Textbook of Biochemistry with Clinical Correlations,
3rd ed., TM Devlin (ed), Wiley-Liss, NY 1992 pg 8602
- UniProt :accession P01185
- GeneReviews
http://www.ncbi.nlm.nih.gov/sites/genetests/lab/gene/AVP
- Wikipedia; Note: vasopressin entry
http://en.wikipedia.org/wiki/vasopressin