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oxytocin-neurophysin 1; OT-NPI; contains: oxytocin; neurophysin 1 (OXT, OT)
Function:
- precursor for
- oxytocin
- oxytocin causes contraction of the smooth muscle of the uterus & of the mammary gland
- neurophysin 1
- neurophysin 1 specifically binds oxytocin
Structure:
- belongs to the vasopressin/oxytocin family
Compartment: secreted
Pharmacology:
- oxytocin is available under the names pitocin (Parke-Davis) & syntocinon (Sandoz)
- used to artificially speed or induce labor
General
glycoprotein
peptide precursor
protein precursor
Properties
SIZE: entity length = 125 aa
MW = 13 kD
MOTIF: signal sequence {1-19}
cysteine residue {C20}
MODIFICATION: cysteine residue {C25}
cysteine residue {C25}
MODIFICATION: cysteine residue {C20}
cysteine residue {C41}
MODIFICATION: cysteine residue {C85}
cysteine residue {C44}
MODIFICATION: cysteine residue {C58}
cysteine residue {C52}
MODIFICATION: cysteine residue {C75}
cysteine residue {C58}
MODIFICATION: cysteine residue {C44}
cysteine residue {C59}
MODIFICATION: cysteine residue {C65}
cysteine residue {C65}
MODIFICATION: cysteine residue {C59}
cysteine residue {C75}
MODIFICATION: cysteine residue {C52}
cysteine residue {C85}
MODIFICATION: cysteine residue {C41}
cysteine residue {C92}
MODIFICATION: cysteine residue {C104}
cysteine residue {C98}
MODIFICATION: cysteine residue {C116}
cysteine residue {C104}
MODIFICATION: cysteine residue {C92}
cysteine residue {C105}
MODIFICATION: cysteine residue {C110}
cysteine residue {C110}
MODIFICATION: cysteine residue {C105}
cysteine residue {C116}
MODIFICATION: cysteine residue {C98}
PRECURSOR-FOR: oxytocin
COMPARTMENT: plasma
neurophysin-1
COMPARTMENT: extracellular compartment
Database Correlations
OMIM 167050
UniProt P01178
PFAM correlations
Entrez Gene 5020
Kegg hsa:5020
References
- Textbook of Biochemistry with Clinical Correlations,
3rd ed., TM Devlin (ed), Wiley-Liss, NY 1992 pg 860
- UniProt :accession P01178
- Wikipedia; Note: oxytocin entry
http://en.wikipedia.org/wiki/oxytocin