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protachykinin-1; PPT; preprotachykinin A; contains: substance P; neurokinin A; NKA; neuromedin L; substance K; neuropeptide K; NPK; neuropeptide gamma; C-terminal-flanking peptide (TAC1, NKA, NKNA, TAC2)
Function:
- tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators & secretagogues, & contract (directly or indirectly) many smooth muscles
Structure: belongs to the tachykinin family
Compartment: secreted
Alternative splicing: named isoforms=4; alpha, beta, gamma, delta
Specific
protachykinin alpha
protachykinin beta
protachykinin gamma
General
preprotachykinin
Properties
SIZE: entity length = 129 aa
MW = 15 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-19}
Database Correlations
OMIM 162320
UniProt P20366
Entrez Gene 6863
Kegg hsa:6863
References
- UniProt :accession P20366
- Wikipedia; Note: neurokinin-1 entry
http://en.wikipedia.org/wiki/neurokinin_1