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prenylcysteine oxidase 1; prenylcysteine lyase (PCYOX1, KIAA0908, PCL1, UNQ597/PRO1183)
Function:
- role in degradation of prenylated proteins
- cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine & geranylgeranylcysteine
S-prenyl-L-cysteine + O2 + H2O = a prenal + L-cysteine + H2O2
Cofactor: FAD
Structure:
- glycosylated at one or more potential N-glycosylation sites
- belongs to the prenylcysteine oxidase family
Compartment: lysosome
Expression: ubiquitous
Note: originally thought to be a lyase
Related
prenyl protein
General
glycoprotein
oxidoreductase
Properties
SIZE: entity length = 505 aa
MW = 57 kD
COMPARTMENT: lysosome
MOTIF: signal sequence {1-27}
N-glycosylation site {N196}
N-glycosylation site {N323}
N-glycosylation site {N353}
Database Correlations
OMIM 610995
UniProt Q9UHG3
PFAM correlations
Entrez Gene 51449
Kegg hsa:51449
ENZYME 1.8.3.5
References
UniProt :accession Q9UHG3