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prekallikrein
Normally exists in plasma in a 1:1 complex with HMW kininogen. Both are coordinately activated with the contact system yielding kallikrein & kinins.
Interactions
molecular events
Related
contact system
high molecular weight [HMW] kininogen; alpha-2 thiol proteinase inhibitor (KNG1)
kallikrein
prekallikrein (Fletcher Factor) in plasma
General
coagulation factor
protein precursor
Properties
SIZE: MW = 88 kD
COMPARTMENT: plasma
MOTIF: proteolytic site
PRECURSOR-FOR: kallikrein
COMPARTMENT: plasma
MOTIF: charge relay system
MOTIF: aspartate residue
histidine residue
serine residue
References
- Clinical Diagnosis and Management by Laboratory Methods,
18th ed, J.B. Henry (ed), W.B. Saunders, Philadelphia,
PA, 1991 pg 735
- Stedman's Medical Dictionary 27th ed, Williams &
Wilkins, Baltimore, 1999
Component-of
molecular complex