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prediction of dementia
Laboratory:
- plasma proteomic profiles predict dementia 10 years in advance [1]
- plasma GFAP, NEFL, GDF15 & LTBP2 consistently associated with dementia
- people with higher plasma GFAP are 2.3 times more likely to develop dementia
- plasma GFAP identified as optimal marker for prediction of dementia
Notes:
- there is a dementia risk calculator based on clinical factors
- an MRI score is said to predict dementia [2]
- cardiovascular risk factors are said to predict dementia in CAIDE trial
- there is discussion of predicting dementia in primary care [3]
- artificial intelligence analyzed voice recordings may help predict which patients with mild cognitive impairment develop will Alzheimer's dementia within 6 years [4]
References
- Naddaf M
Early dementia diagnosis: blood proteins reveal at-risk people.
Nature News. 2024 Feb 12
PMID: 38347211
https://www.nature.com/articles/d41586-024-00418-9
- Guo Y, You J, Zhang Y et al
Plasma proteomic profiles predict future dementia in healthy adults.
Nature Aging. 2024. Feb 12.
PMID: 38347190
https://www.nature.com/articles/s43587-023-00565-0
- Amin Al Olama A et al.
Simple MRI score aids prediction of dementia in cerebral small
vessel disease.
Neurology 2020 Mar 24; 94:e1294.
PMID: 32123050
https://n.neurology.org/content/94/12/e1294
- Jongstra S, van Gool WA, Moll van Charante EP et al
Improving Prediction of Dementia in Primary Care.
Ann Fam Med May/June 2018 vol. 16 no. 3 206-210
PMID: 29760023 Free Article
http://www.annfammed.org/content/16/3/206
- George J
AI Helps Predict Dementia Using Speech Patterns.
Voice recordings may spot who's likely to progress to Alzheimer's
dementia in 6 years.
MedPage Today June 26, 2024
https://www.medpagetoday.com/neurology/alzheimersdisease/110843
- Amini S, Hao B, Yang J, Karjadi C, Kolachalama VB, Au R, Paschalidis IC.
Prediction of Alzheimer's disease progression within 6 years using speech:
A novel approach leveraging language models.
Alzheimers Dement. 2024 Jun 25.
PMID: 38924662
https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.13886