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PRC2/EED-EZH1 complex
Function:
- methylates Lys-27 of histone H3, leading to transcriptional repression of the affected target genes
- able to mono-, di- & trimethylate Lys-27 of histone H3
- required for embryonic stem cell derivation & self-renewal
Structure:
- subunits include EED, EZH1, SUZ12, RBBP4 & AEBP2
- EZH1 is catalytic subunit
Expression:
- less abundant than the PRC2/EED-EZH2 complex
Related
Polycomb group multiprotein PRC1 complex (PcG PRC1 complex, hPRC-H, PcG repressive complex 1)
Polycomb group multiprotein PRC2 complex; PRC2/EED-EZH2 complex; EZH2 histone methyltransferase complex (PcG)
General
molecular complex
Properties
SUBUNITS: histone-lysine N-methyltransferase EZH1
COMPARTMENT: cell nucleus
MOTIF: nuclear translocation signal {491-496}
cysteine-rich region {524-606}
SET domain {612-732}
polycomb protein EED
COMPARTMENT: cell nucleus
MOTIF: EZH2 interaction {81-441}
MOTIF: WD repeat {91-134}
WD repeat {142-185}
HIV1-MA interaction {149-303}
WD repeat {188-228}
WD repeat {234-275}
HIV1-MA interaction {301-441}
WD repeat {304-341}
WD repeat {359-399}
WD repeat {408-441}
polycomb protein SUZ12
COMPARTMENT: cell nucleus
MOTIF: glycine-rich region {7-50}
serine-rich region {51-59}
MOTIF: serine residue (SEVERAL)
alanine-rich region {60-67}
MOTIF: alanine residue (SEVERAL)
Zn finger C2H2-type
SITE: 448-471
EFFECTOR-BOUND: Zn+2
Ser phosphorylation site {S546}
VEFS-box. {563-639}
histone-binding protein RBBP4
COMPARTMENT: cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
WD repeat {122-155}
WD repeat {175-206}
WD repeat {225-256}
WD repeat {271-302}
WD repeat {315-346}
WD repeat {372-403}
zinc finger protein AEBP2
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S18}
Ser phosphorylation site {S24}
Ser phosphorylation site {S27}
glutamate-rich region {34-123}
MOTIF: glutamate residue (SEVERAL)
glycine-rich region {61-205}
serine-rich region {110-256}
MOTIF: serine residue (SEVERAL)
RBBP4 interaction {209-294}
MOTIF: Zn finger C2H2-type
SITE: 261-286
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 300-322
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 328-352
EFFECTOR-BOUND: Zn+2
SUZ12 interaction {353-517}
References
UniProt :accession Q92800
Components
histone-binding protein RBBP4; retinoblastoma-binding protein 4; RBBP-4; retinoblastoma-binding protein p48; chromatin assembly factor 1 subunit C; CAF-1 subunit C; chromatin assembly factor I p48 subunit; CAF-I 48 kD subunit; CAF-I p48; nucleosome-remodeling factor subunit RBAP48 (RBBP4, RbAp48)
histone-lysine N-methyltransferase EZH1; ENX-2; enhancer of zeste homolog 1 (EZH1, KIAA0388)
polycomb protein EED; hEED; WD protein associating with integrin cytoplasmic tails 1; WAIT-1 (EED)
polycomb protein SUZ12 (suppressor of zeste 12 protein homolog, joined to JAZF1 protein, chromatin precipitated E2F target 9 protein, ChET 9 protein, SUZ12, CHET9, JJAZ1, KIAA0160)
zinc finger protein AEBP2 (adipocyte enhancer-binding protein 2, AE-binding protein 2, AEBP2)