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parathyroid adenomatosis [PRAD]-1 gene, CCND1 or bcl-1

PRAD for parathyroid adenomatosis. Pathology: - the PRAD1 gene was originally identified as a clonally rearranged & overexpressed gene linked to the bcl-1 locus in a set of benign parathyroid tumors. - chromosomal translocation & gene amplification of PRAD1 has also been demonstrated in: a) esophageal cancer b) mantle cell lymphoma c) breast cancer d) head & neck cancer e) hepatocellular carcinoma

Related

cyclin D1 (parathyroid adenomatosis-1 [PRAD1] protein or bcl-1 proto-oncogene protein, CCND1, BCL1) parathyroid adenoma

General

proto-oncogene

Properties

TEMPLATE-FOR: messenger RNA TEMPLATE-FOR: cyclin D1 LOCUS: human chromosome-11 Q13 MOTIF: EkB site transcriptional start site exon intron transcriptional termination site

Database Correlations

OMIM correlations

References

  1. Motokura T, Bloom T, Kim HG, Juppner H, Ruderman JV, Kronenberg HM, Arnold A. A novel cyclin encoded by a bcl1-linked candidate oncogene. Nature. 1991 Apr 11;350(6318):512-5. PMID: 18265421
  2. Jiang W, Kahn SM, Tomita N, Zhang YJ, Lu SH, Weinstein IB. Amplification and expression of the human cyclin D gene in esophageal cancer. Cancer Res. 1992 May 15;52(10):2980-3. PMID: 1533816
  3. OMIM :accession 151400
  4. Harrison's Principles of Internal Medicine, 14th ed. Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 506
  5. Hinz et al. Mol & Cell Biol 19:2690-98, 1999