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POU domain, class 2, transcription factor 3 (octamer-binding transcription factor 11, Oct-11, transcription factor Skn-1, PLA-1 protein, POU2F3, OTF11, PLA1)
Function:
1) transcription factor binds to the octamer motif (5'-ATTTGCAT-3')
2) regulates expression of genes, including SPRR2A or placental lactogen
Structure:
- belongs to the POU transcription factor family, class-2 subfamily
- contains 1 homeobox DNA-binding domain
- contains 1 POU-specific domain
Compartment: nucleus
Expression:
- specifically expressed in epidermis & cultured keratinocytes
General
transcription factor (TF)
Properties
SIZE: MW = 47 kD
entity length = 436 aa
COMPARTMENT: cell nucleus
MOTIF: POU domain
SITE: 183-257
homeodomain
SITE: 281-340
serine-rich region {354-425}
MOTIF: serine residue (SEVERAL)
Database Correlations
OMIM 607394
UniProt Q9UKI9
PFAM correlations
References
UniProt :accession Q9UKI9