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potassium iodide (KI, Thyro-Block, Irostat)
Indications:
- source of essential nutrient iodide
- blocks uptake of radioactive iodine [6]
Dosage:
1) 1 tab PO QD
2) 16 mg for neonates
3) up to 130 mg for adults
Contraindications:
pregnancy-category D
safety in lactation ?
Pharmacokinetics:
- the iodine is reduced to iodide in the intestine before absorbtion
Mechanism of action:
1) iodide limits its own transport & inhibits synthesis of iodotyrosine & iodothyronine (Wolf-Chaikoff effect, 1948) due to increased intracellular iodide [5]
2) blocks accumulation of radioactive iodine by the thyroid [6]
Notes:
- relative amounts of iodine & iodide in Thyro-Block & Irostat are not known; however, the principle of its effects are probably similar to Lugol's solution.
Related
Lugol's solution (iodine/iodide)
Specific
saturated solution of potassium iodide (SSKI)
General
salt
metabolic agent (metabolic modifier)
Database Correlations
PUBCHEM correlations
References
- Drug Information & Medication Formulary, Veterans Affairs,
Central California Health Care System, 1st ed., Ravnan et al
eds, 1998
- http://www.anbex.com
- Goodman and Gilman's The Pharmacological Basis of
Therapeutics, 8th ed. Gilman et al, eds.
Permagon Press/McGraw Hill, 1990. pg 1014-6
- Prescriber's Letter 8(12):71 2001
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996 pg 1402
- Frequently Asked Questions About Potassium Iodide
United States Nuclear Regulatory Commission (USNRC)
http://www.nrc.gov/about-nrc/emerg-preparedness/about-emerg-preparedness/potassium-iodide/ki-faq.html
- Prescriber's Letter 18(3): 2011
Potassium Iodide (KI): Frequently Asked Questions
Detail-Document#: 270323
(subscription needed) http://www.prescribersletter.com
- Department of Veterans Affairs, VA National Formulary
Component-of
alpha tocopherol/ascorbate/calcium citrate/carbonyl iron/cholecalciferol/docosahexaenoate/folic acid/nicotinamide/potassium iodide/pyridoxine/riboflavin/sodium docusate/thiamine/zinc oxide
alpha tocopherol/ascorbate/calcium citrate/carbonyl iron/cholecalciferol/folic acid/nicotinamide/potassium iodide/pyridoxine/riboflavin/sodium docusate/thiamine/zinc oxide
alpha tocopheryl acetate/ascorbate/calcium carbonate/cobalamin/copper sulfate/ferrous fumarate/folic acid/magnesium oxide/nicotinamide/potassium iodide/pyridoxine/retinol/riboflavin/thiamine/vitamin d/zinc sulfate
ammonium chloride/potassium iodide
ascorbate/calcium carbonate/cholecalciferol/choline bitartrate/cobalamin/docosahexaenoate/eicosapentaenoate/ferrous fumarate/folic acid/nicotinic acid/potassium iodide/pyridoxine/riboflavin/thiamine/vitamin e/zinc oxide
ascorbate/cholecalciferol/cobalamin/folic acid/magnesium oxide/nicotinic acid/polysaccharide iron complex/potassium iodide/pyridoxine/riboflavin/thiamine/vitamin a/vitamin e/zinc oxide
chlorpheniramine/codeine/phenylephrine/potassium iodide
dextromethorphan/potassium iodide
ephedrine/phenobarbital/potassium iodide/theophylline
ephedrine/potassium iodide
iodine/isopropanol/potassium iodide
iodine/potassium iodide
potassium iodide/theophylline